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Gravediggers negates the effect of monster effects activating in the hand, grave or banished, then does 2000 burn damage to an injury to insult, and is how Rafflesia protects us from Nibiru

One of the oldest kindred types in Magic: The Gathering, Angels can be a powerful force on the battlefield in the right deck

These are powerful, and running enough of them can mitigate the need for the cards on this list, but theyre so flexible they would naturally top the list (I do have a few spells that target permanents other than artifacts, but they still say artifact)

1 Lizard Blades

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If there are none, the monster may attack the opponent directly